2000 AD is a comic book. Lets not get carried away here. The format is definitely unique (weeeeeeell, the monthly/weekly anthology format is actually pretty damn popular in Japan. They certainly have more then one title in the format too) and a tough sell to Joe American Comic Reader. But, honestly, I think the cost and availability is the only thing holding it back from being moderately successful over here.
If Rebellion teamed up with Image or Dark Horse to publish 2000 AD domestically, I think it could have a fair shake. Hell, I'd be for a slight format change to make it even more accessible, take a month's worth of progs, and bind them together in one monthly book. A 100 page monster each month with the contents of the equivalent progs inside. That would get US reader's attention, and be something they could digest/understand format wise.
EDIT: I would also totally and without question buy the Prog (and Meg) if it was avalible on ComiXology's Comics App. All day, every day, till the end of days.
At any rate, S&S trades own. I got my copy of DR & Quinch and couldn't be happier. A)Price is much cheaper then importing was. B)Tradedress is the same (SPINES!) C)Same quality as before. Best thing ever. Now lets see if the line lasts, I have my fears after the DC debacle.