It's interesting to me that lots of the people I consider at the cutting edge of comics (people into experimentation with the form - like warren ellis) have started to refer to comics as 'artifacts' - ie actual non-digital things. I see two things in the future:
1) Digital comics, almost all marvel / dc / 2000AD / small press (which will be distinct from marvel / dc / 2000AD only in as much as the creators will probably never had anything in physical print) You could argue that many of those people doing webcomics now are actually getting a bigger readership than Marvel /DC/Whoever, but, because they're all digital we think of them as small press.
2) 'Artifacts' - like the big absolute collections, these will be premier books - I'd still like the big dredd collections, etc, or collected works, but I'd be happy to buy 2000AD and the Meg digitially, picking up collections along the way. (I'd even pay! though not the current barmy pricing of £1.89 or so for the digital 2000ad, not when the actual print copy is roughly the same - the meg digital price, on the other hand, is a bargain)
Course we're a long way from that ideal, but I can see it shaping up like that and I'm looking forward to it.
What's stopping us right now is the idea of a device for reading comics, the iPhone is great and suggests a perfect distribution model that might work, but the form is just too small (even if you make use of it properly by treating each screen as a page). Some kind of tablet is inevitable (for a number of reasons) publishers want it, computer manufacturers want it (lets face it, most of us have computers now that we're probably never going to replace unless we really have the money spare - seriously, I haven't pushed the power of my own computer for a few years, though, granted I don't play games) and the technology is shaping up to make a tablet sized device something that can work well and be affordable.
It's all a question of when (and can print publishers survive long enough to actually capitalise on it when it happens).
(As an aside, I think 2000AD should be looking at distributing through longbox/iVerse AND comixology, frankly the more venues the better)
(Also: most people I know colour on computer, some draw on computer, going to print often DOES have an impact on the art - mostly negative as we've all lost knowledge on how to go to print properly...)
-pj
(ps cheers for this, it's probably a good basis for a another show)